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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

T-type calcium channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (35) Apoptosis (1) Caspase (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (7) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (27)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Calcium Channel CRAC Channel CaSR Calmodulin Chloride Channel HCN Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10035

TTA-P2 T-type calcium channel inhibitor	Calcium Channel	Neurological Disease
TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .

HY-50707

(Rac)-TTA-P2 (Rac)-T-type calcium channel inhibitor	Others	Neurological Disease
(Rac)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .

HY-147708

T-Type calcium channel inhibitor 2	Calcium Channel	Cancer
T-Type calcium channel inhibitor 2 (compound 6g) is a potent **T-type calcium channel inhibitor with IC₅₀*s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type* calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC₅₀s of 5.0, 6.4 µM, respectively .

HY-150539

IAB15

Calcium Channel Neurological Disease

IAB15 is a potent T-type calcium channel inhibitor. IAB15 can be used for epilepsy research .
HY-150541

IAA65

Calcium Channel Neurological Disease

IAA65 is a potent T-type calcium channel inhibitor with a IC₅₀ value of 18.9 µM. IAA65 can be used for epilepsy research .

IAB15	Calcium Channel	Neurological Disease
IAB15 is a potent **T-type calcium channel** inhibitor. IAB15 can be used for epilepsy research .

IAA65	Calcium Channel	Neurological Disease
IAA65 is a potent **T-type calcium channel inhibitor with a IC₅₀** value of 18.9 µM. IAA65 can be used for epilepsy research .

HY-10035A

(R)-TTA-P2	Others	Neurological Disease
(R)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .

HY-10955

TTA-P1	Calcium Channel	Neurological Disease
TTA-P1 is a potent state-independent compound inhibiting human T-type calcium channel. T-type calcium channels play a role in diverse physiological responses including neuronal burst firing, hormone secretion, and cell growth. TTA-P1 has the potential for the research of absence epilepsy .

HY-14232

TTA-A8	Calcium Channel	Neurological Disease
TTA-A8 (Compound 13) is a short-acting **T-type calcium channel** antagonist with oral activity, exhibiting an IC₅₀ value of 31.3 nM in the FLIPR depolarization assay. TTA-A8 possesses favorable pharmacokinetic properties, making it suitable for research on epilepsy and sleep .

HY-A0092

Trimethadione 3,5,5,-Trimethyloxazolidine-2,4-dione	Calcium Channel	Neurological Disease
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type **calcium channel** blocker which has antihyperalgesic effects .

HY-147638

MONIRO-1	Calcium Channel	Neurological Disease
MONIRO-1 is a T-type and N-type **calcium channel blocker with IC₅₀ values of 34, 3.3, 1.7 and 7.2 µM against hCa_v2.2, hCa_v3.1, hCa_v3.2 and hCa_v3.3**, respectively .

HY-B0768A

Lomerizine dihydrochloride

KB-2796
Calcium Channel Neurological Disease

Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels.

Lomerizine dihydrochloride KB-2796	Calcium Channel	Neurological Disease
Lomerizine dihydrochloride is an antagonist of L- and **T-type voltagegated calcium channels**.

HY-15553A

Mibefradil dihydrochloride Maximum Cited Publications 9 Publications Verification Ro 40-5967 dihydrochloride	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a **calcium channel** blocker with moderate selectivity for T-type Ca ²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) .

HY-15553

Mibefradil Ro 40-5967	Calcium Channel	Cardiovascular Disease
Mibefradil (Ro 40-5967) is a **calcium channel** blocker with moderate selectivity for T-type Ca ²⁺ channels displaying IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively .

HY-12502

Efonidipine

NZ-105; (±)-Efonidipine
Calcium Channel Cardiovascular Disease

Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
HY-12502B

Efonidipine hydrochloride

NZ-105 hydrochloride
Calcium Channel Cardiovascular Disease

Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
HY-101096

Suvecaltamide

MK-8998
Calcium Channel Neurological Disease

Suvecaltamide (MK-8998; compound 33) is a potent and selective inhibitor of the T-type calcium channel.

Efonidipine NZ-105; (±)-Efonidipine	Calcium Channel	Cardiovascular Disease
Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).

Efonidipine hydrochloride NZ-105 hydrochloride	Calcium Channel	Cardiovascular Disease
Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).

Suvecaltamide MK-8998	Calcium Channel	Neurological Disease
Suvecaltamide (MK-8998; compound 33) is a potent and selective inhibitor of the T-type **calcium channel**.

HY-50722

NNC 55-0396 4 Publications Verification NNC 55-0396 dihydrochloride	Calcium Channel	Cardiovascular Disease Neurological Disease
NNC 55-0396 is a highly selective **T-type calcium channel blocker with an IC₅₀** value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research .

HY-111828

TTA-A2 1 Publications Verification	Calcium Channel	Neurological Disease
TTA-A2 is a potent, selective and orally active **t-type voltage gated calcium channel** antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a₁G) and Cav3.2 (a₁H) channels with IC₅₀ values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy .

HY-12502A

Efonidipine hydrochloride monoethanolate NZ-105 hydrochloride monoethanolate	Calcium Channel	Cardiovascular Disease
Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).

HY-120546

Ulixacaltamide Z944	Calcium Channel	Neurological Disease
Ulixacaltamide (Z944) is an orally active **T-type calcium channel** antagonist that rescues impairments in crossmodal and visual recognition memory.

HY-P1078

Huwentoxin XVI	Calcium Channel	Neurological Disease
Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels .

HY-P1078A

Huwentoxin XVI TFA	Calcium Channel	Neurological Disease
Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels .

HY-B1378

Ethosuximide	Calcium Channel	Neurological Disease Cancer
Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type **calcium channel**.

HY-161076

KTt-45

Caspase Apoptosis Calcium Channel Cancer

KTt-45 is a T-type calcium channel blocker. KTt-45 has anticancer effect by inducing apoptosis on HeLa cervical cancer cell line .

KTt-45	Caspase Apoptosis Calcium Channel	Cancer
KTt-45 is a **T-type calcium channel blocker. KTt-45 has anticancer effect by inducing apoptosis** on HeLa cervical cancer cell line .

HY-112723

Apinocaltamide ACT-709478	Calcium Channel	Neurological Disease
Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating **T-type calcium channel** blocker. ACT-709478 is used in the research of generalized epilepsies .

HY-B1378S

Ethosuximide-d3	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Ethosuximide-d₃ is the deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel[1][2].

HY-W032013

1-Octanol Octanol	Calcium Channel Endogenous Metabolite	Neurological Disease Metabolic Disease
1-Octanol (Octanol), a saturated fatty alcohol, is a **T-type calcium channels (T-channels) inhibitor with an IC₅₀** of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-B1378S1

Ethosuximide-d5	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Ethosuximide-d₅ is deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

HY-151450

Cav 3.2 inhibitor 1	Calcium Channel	Neurological Disease Inflammation/Immunology
Cav 3.2 inhibitor 1 is a T-type **calcium channel** inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain .

HY-154832

Cav 3.2 inhibitor 4	Calcium Channel	Cardiovascular Disease
Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Ca_v3.2) inhibitor, with an IC₅₀ of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation .

HY-W032013S

1-Octanol-d17 Octanol-d₁₇	Calcium Channel Endogenous Metabolite
1-Octanol-d₁₇ is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].

HY-W032013S1

1-Octanol-d2 Octanol-d₂	Calcium Channel Endogenous Metabolite
1-Octanol-d₂ is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .

HY-103309

ML218	Calcium Channel	Neurological Disease
ML218 is a potent, selective and orally active T-type Ca ²⁺ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier .

HY-103309A

ML218 hydrochloride	Calcium Channel	Neurological Disease
ML218 hydrochloride is a potent, selective and orally active T-type Ca ²⁺ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 hydrochloride inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 hydrochloride has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG potassium channels. ML218 hydrochloride can penetrate the blood-brain barrier .

HY-103309S

ML218-d9	Calcium Channel	Neurological Disease
ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

HY-147639

Cav 2.2/3.2 blocker 1	Calcium Channel	Neurological Disease
Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC₅₀ values of 78 μM and 80 μM against Ca_v2.2 and Ca_v3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS .

Huwentoxin XVI	Calcium Channel	Neurological Disease
Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels .

Huwentoxin XVI TFA	Calcium Channel	Neurological Disease
Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels .

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W032013

1-Octanol Octanol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Calcium Channel Endogenous Metabolite
1-Octanol (Octanol), a saturated fatty alcohol, is a **T-type calcium channels (T-channels) inhibitor with an IC₅₀** of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

Cat. No.	Product Name	Chemical Structure

HY-W032013S

1-Octanol-d17
1-Octanol-d₁₇ is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].

HY-B1378S

Ethosuximide-d3
Ethosuximide-d₃ is the deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel[1][2].

HY-B1378S1

Ethosuximide-d5
Ethosuximide-d₅ is deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

HY-W032013S1

1-Octanol-d2
1-Octanol-d₂ is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3].

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

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